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Index > Protein center > Fkbp8(Gene name) > Mouse
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  • Fkbp8 (Gene name),
  • Peptidyl-prolyl cis-trans isomerase FKBP8 (Protein name ),  FKBP8_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Fkbp8(Fkbp38;Sam11);
    Protein name:
    Peptidyl-prolyl cis-trans isomerase FKBP8(PPIase FKBP8);
    Alternative:
    FK506-binding protein 8(FKBP-8);38 kDa FK506-binding protein(38 kDa FKBP;FKBP-38;mFKBP38);Rotamase;FKBPR38;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Homomultimers or heteromultimers (Potential). Forms heterodimer with calmodulin. When activated by calmodulin and calcium, interacts with the BH4 domain of BCL2 and weakly with BCLX isoform Bcl-X(L). Does not bind and inhibit calcineurin (By similarity). Interacts with ZFYVE27; may negatively regulate ZFYVE27 phosphorylation.
    Function:
    Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis (By similarity). Required for normal embryonic development.
    Subcellular Location:
    Mitochondrion membrane Single-pass membrane protein Cytoplasmic side
    Protein Attributes:
    Sequence length:
    402
    Sequence:
    50:
    MASWAEPSEP | AALRLPGAPL | LEGFEVLDGV | DDAEEEDDLS | GLPPLEDMGQ | 
    100:
    PTVEEAEQPG | ALAREFLAAT | EPEPAPAPAP | EEWLDILGNG | LLRMKTLVPG | 
    150:
    PKGSSRPLKG | QVVTVHLQMS | LENGTRVQEE | PELAFTLGDC | DVIQALDLSV | 
    200:
    PLMDVGETAM | VTADSKYCYG | PQGRSPYIPP | HAALCLEVTL | KTAEDGPDLE | 
    250:
    MLSGQERVAL | ANRKRECGNA | HYQRADFVLA | ANSYDLAIKA | ITSNTKVDMT | 
    300:
    CEEEEELLQL | KVKCLNNLAA | SQLKLDHYRA | ALRSCSQVLE | HQPDNIKALF | 
    350:
    RKGKVLAQQG | EYSEAIPILR | AALKLEPSNK | TIHAELSKLV | KKRAAQRSTE | 
    400:
    TALYRKMLGN | PSRLPAKCPG | KGAWSIPWKW | LFGATAVALG | GVALSVVIAA | 
    402:
    RN
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    String:
    Pfam:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse PPIase FKBP8
    Cat.:
    E11198h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse PPIase FKBP8
    Cat.:
    E11198m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse PPIase FKBP8
    Cat.:
    E11198r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse PPIase FKBP8
    Cat.:
    U11198h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse PPIase FKBP8
    Cat.:
    U11198m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse PPIase FKBP8
    Cat.:
    U11198r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse PPIase FKBP8
    Cat.:
    P11198Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse PPIase FKBP8
    Polyclonal Antibody for Mouse PPIase FKBP8
    Monoclonal Antibody for Mouse PPIase FKBP8
    Monoclonal Antibody for Mouse PPIase FKBP8
    Monoclonal Antibody for Mouse PPIase FKBP8
    Protein for Mouse PPIase FKBP8
    Protein for Mouse PPIase FKBP8
    Protein for Mouse PPIase FKBP8

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis."
      Shirane M. , Nakayama K.I.
      Nat. Cell Biol.5:28-37(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INTERACTION WITH BCL2 AND BCL2L1/BCLXL
    2. 2.
      "FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues."
      Bulgakov O.V. , Eggenschwiler J.T. , Hong D.-H. , Anderson K.V. , Li T.
      Development131:2149-2159(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      strain: BALB/c.
      strain: C57BL/6J.
      strain: NOD.
      tissue: Bone marrow macrophage.
      tissue: Placenta.
      tissue: Spleen.
      tissue: Thymus.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      strain: FVB/N.
      tissue: Mammary tumor.
    5. 5.
      "muFKBP38: a novel murine immunophilin homolog differentially expressed in Schwannoma cells and central nervous system neurons in vivo."
      Pedersen K.M. , Finsen B. , Celis J.E. , Jensen N.A.
      Electrophoresis20:249-255(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 39-402 (ISOFORM 1);SUBUNIT;TISSUE SPECIFICITY
      strain: C57BL/6 X DBA/2.
    6. 6.
      "Fkbp8: novel isoforms, genomic organization, and characterization of a forebrain promoter in transgenic mice."
      Nielsen J.V. , Mitchelmore C. , Pedersen K.M. , Kjaerulff K.M. , Finsen B. , Jensen N.A.
      Genomics83:181-192(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 48-402;SEQUENCE REVISION TO 100 AND 400;ALTERNATIVE SPLICING;TISSUE SPECIFICITY
      strain: 129/SvJ.
    7. 7.
      "Regulation of apoptosis and neurite extension by FKBP38 is required for neural tube formation in the mouse."
      Shirane M. , Ogawa M. , Motoyama J. , Nakayama K.I.
      Genes Cells13:635-651(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
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